Breakpoints

Join host Dr. Julie Ann Justo and guests Drs. Conan MacDougall and Majdi Al-Hasan for the second installment of a two-part series on IV to PO antibiotic transition. Turning the focus to gram-negative infections, this episode explores the evidence for oral therapy, how to choose among agents like fluoroquinolones, trimethoprim-sulfamethoxazole, and beta-lactams, key dosing and PK/PD considerations, patient selection and safety, and practical strategies for implementing early IV to PO transition in clinical practice.

References:

1.       POET: Iversen K, et al. Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis. N Engl J Med. 2019 Jan 31;380(5):415-424. doi: 10.1056/NEJMoa1808312. …

Join host Dr. Julie Ann Justo and guests Drs. Nicholas Mercuro and Andrew Haynes for the first installment of a two-part series on IV to PO antibiotic transition. Building on landmark studies such as POET, OVIVA, and SABATO, this episode explores the evidence supporting oral therapy for gram-positive bacterial infections, practical implementation strategies, pharmacokinetic and pharmacodynamic considerations, pediatric perspectives, and areas where clinicians may still have concerns about transitioning from IV to PO therapy.

References:

1.       https://sidp.org/SIDPEC, search for on-demand CE course from Drs. Jonathan Ryder & Esther Golnabi entitled, "Breaking Points: Landmark Studies that Shaped Infectious…

Join host Dr. Whitney Buckel and guests Drs. Priya Nori and Brad Langford as they highlight recent publications from Antimicrobial Stewardship & Healthcare Epidemiology (ASHE). This episode explores antimicrobial stewardship workforce trends, leadership competencies, innovative educational strategies, and environmental sustainability, with practical takeaways to help stewardship professionals strengthen programs and advance patient care

References:

1. Breakpoints: The SIDP Podcast. Episode 133: Trash Talk: Earth Day Special on Healthcare Sustainability and Stewardship. Released on April 16, 2026. Available at:Breakpoints website
2. CASCADES website: CASCADES – Creating a Sustainable Canadian Health System in a Climate…

Join host Dr. Ryan Moenster and guests Drs. Kaitlyn Rivard and Ross England as they discuss current strategies for preventing RSV in infants. Topics include maternal vaccination, long-acting monoclonal antibodies, differences between available products, safety considerations, vaccine hesitancy, and practical implementation strategies to help protect infants from severe RSV disease. Don't miss this timely discussion packed with expert insights and practical pearls for clinicians caring for infants and families during RSV season.

Funding for this podcast was provided by Sanofi

Reference:

1.      Hammitt LL, Dagan R, Yuan Y, et al. …

Does oseltamivir harm critically ill patients with influenza? In this Breakpoints and Communicable collaboration, Erin McCreary and Josh Davis are joined by Steve Webb and Steve Tong to discuss the REMAP-CAP trial results that are challenging a long-standing intensive care practice. Together, they review the study design, key findings, and implications for clinical care, while highlighting the importance of randomized clinical trials in shaping evidence-based medicine. At the time of recording, the REMAP-CAP results were available as a preprint.

Resources:

· REMAP-CAP: A Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired Pneumonia, https://www.remapcap.org/ …

Dr. Prathit Kulkarni, lead author of a recent state-of-the-art review on acute and chronic bacterial prostatitis, joins host Dr. Erin McCreary to discuss this complex disease state. They walk through diagnosis, epidemiology, treatment, and more. You won’t want to miss this episode!

References:

1. Kulkarni PA, Cortés-Penfield NW, Brehm TJ, et al. State-of-the-Art Review: Diagnosis and Management of Acute and Chronic Bacterial Prostatitis. Clin Infect Dis. 2026;82(1):1-13. doi:10.1093/cid/ciaf483

Learn more about the Society of Infectious Diseases Pharmacists: SIDP - About

Instagram: @SIDPharm ( https://www.instagram.com/sidpharm/) or @breakpointspodcast_sidp…

Gram-negative resistance is beautifully intricate, scientifically elegant, and very complex. Nothing is more exciting than the recently approved and bursting pipeline of beta-lactamase inhibitors. Listen to Drs. Sam Aitken and Christophe Le Terrier, along with host Dr. Erin McCreary, describe the nuanced enzymology and other antibacterial properties of beta-lactamase inhibitors. This episode also discusses the concepts of stand-alone inhibitors, resistance development, and more. If you want to learn more about sulbactam, clavulanic acid, tazobactam, avibactam, relebactam, vaborbactam, durlobactam, enmetazobactam, zidebactam, nacubactam, ledaborbactam, taniborbactam, and xeruborbactam – this episode is for you!

Funding for this podcast was provided by Shionogi Inc.

References: …

Join Dr.  Whitney Buckel and leading HIV experts Dr. William Short and Dr. Ryan Tomlin for an engaging discussion on the current and future state of HIV care. As treatment and prevention options continue to evolve, clinicians face new opportunities and challenges in translating evidence into practice. This episode examines long-acting therapies, prevention innovations, and key implementation considerations, providing practical guidance and real-world perspectives to help healthcare professionals deliver high-quality, evidence-based HIV care.

Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

Instagram: @SIDPharm ( https://www.instagram.com/sidpharm/) or @breakpointspodcast_sidp (https://www.instagram.com/breakpointspodcast_sidp/) https://www.instagram.com…

In this must-listen episode, Dr. Ryan Moenster is joined by Dr. Monica Mahoney and Dr. Mark Gilchrist to dive deep into the evolving landscape of outpatient parenteral antimicrobial therapy (OPAT) and complex outpatient antimicrobial therapy (CoPAT), highlighting real-world challenges, patient selection, and emerging treatment strategies. Navigating outpatient antimicrobial management can be complex, but this episode breaks down key insights and practical applications to help clinicians optimize care beyond the hospital.

References:

1.       Noble AL, Patel S, Birnie E, et al. 2026 updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK. JAC Antimicrob Resist. 2026;8(2). …

In this must-listen episode, Dr. Ryan Moenster and Dr. Megan Klatt dive deep into the latest infectious diseases trials, guidelines, and novel therapeutics. Staying current in the field is a challenge, but this podcast episode does the legwork for you.

Note: BCIDP credit is available for this episode.

Google Drive to Slides from Live Session: [https://drive.google.com/file/d/11uHzZoValckfsjUTIdVyAJ35QDSVRfQu/view?usp=sharing](https://drive.google.com/file/d/11uHzZoValckfsjUTIdVyAJ35QDSVRfQu/view?usp=sharing "https://drive.google.com/file/d/11uHzZoValckfsjUTIdVyAJ35QDSVRfQu/view?usp=sharing")

How to Obtain BCIDP Recertification Credit for this Episode: Visit https://sidp.org/BCIDPhttps://sidp.org/BCIDPSIDP - BCIDP Recertification for more information …